Reflexiones previas sobre la enseñanza de E/LE a inmigrantes y refugiados .

Sin resume

Amino acid tissue levels and GABAa receptor binding in the developing rat cerebellum following status epilepticus

Incidence of status epilepticus (SE) is higher in children than in adults and SE can be induced in developing rats. The cerebellum can be affected after SE; however, consequences of cerebellar amino acid transmission have been poorly studied. The goal of this study was to determine amino acid tissue concentration and GABAA receptor binding in the immature rat cerebellum after an episode of SE. Thirteen-day-old (P13) rat pups received in- traperitoneal injections of lithium chloride (3 mEq/kg). Twenty hours later, on P14, SE was induced by subcutaneous injection of pilocarpine hydrochloride (60 mg/kg). Control ani- mals were given an equal volume of saline subcutaneously. Animals were killed 24 h after SE induction, the cerebellum was quickly removed, and the vermis and hemispheres were rapidly dissected out on ice. Amino acid tissue concentrations in the vermis and hemi- spheres were evaluated by HPLC and fluorescent detection. GABAA receptor binding in the medial vermis was analyzed by in vitro autoradiography. SE increased the tissue levels of the inhibitory amino acids taurine (80%) and alanine (91%), as well as glutamine (168%) in the cerebellar hemisphere; no changes were observed in the vermis. SE did not modify GABAA receptor binding in any cerebellar lobule from the vermis. Our data demonstrate that SE produces region-specific changes in amino acid concentrations in the developing cerebellum

Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild-to-moderate Alzheimer's disease : additional results from the AMBAR study

This study was designed to detect structural and functional brain changes in Alzheimer's disease (AD) patients treated with therapeutic plasma exchange (PE) with albumin replacement, as part of the recent AMBAR phase 2b/3 clinical trial. Mild-to-moderate AD patients were randomized into four arms: three arms receiving PE with albumin (one with low-dose albumin, and two with low/high doses of albumin alternated with IVIG), and a placebo (sham PE) arm. All arms underwent 6 weeks of weekly conventional PE followed by 12 months of monthly low-volume PE. Magnetic resonance imaging (MRI) volumetric analyses and regional and statistical parametric mapping (SPM) analysis on 18 F-fluorodeoxyglucose positron emission tomography (18 FDG-PET) were performed. MRI analyses (n = 198 patients) of selected subcortical structures showed fewer volume changes from baseline to final visit in the high albumin + IVIG treatment group (p < 0.05 in 3 structures vs. 4 to 9 in other groups). The high albumin + IVIG group showed no statistically significant reduction of right hippocampus. SPM 18 FDG-PET analyses (n = 213 patients) showed a worsening of metabolic activity in the specific areas affected in AD (posterior cingulate, precuneus, and parieto-temporal regions). The high-albumin + IVIG treatment group showed the greatest metabolic stability over the course of the study, i.e., the smallest percent decline in metabolism (MaskAD), and least progression of defect compared to placebo. PE with albumin replacement was associated with fewer deleterious changes in subcortical structures and less metabolic decline compared to the typical of the progression of AD. This effect was more marked in the group treated with high albumin + IVIG. (AMBAR trial registration: EudraCT#: 2011-001,598-25; ClinicalTrials.gov ID: NCT01561053). The online version contains supplementary material available at 10.1007/s00259-022-05915-

Characterisation of the upper atmospheres of HAT-P-32 b, WASP-69 b, GJ 1214 b, and WASP-76 b through their He I triplet absorption

Characterisation of atmospheres undergoing photo-evaporation is key to understanding the formation, evolution, and diversity of planets. However, only a few upper atmospheres that experience this kind of hydrodynamic escape have been characterised. Our aim is to characterise the upper atmospheres of the hot Jupiters HAT-P-32 b and WASP-69 b, the warm sub-Neptune GJ 1214 b, and the ultra-hot Jupiter WASP-76 b through high-resolution observations of their HeI triplet absorption. In addition, we also reanalyse the warm Neptune GJ 3470 b and the hot Jupiter HD 189733 b. We used a spherically symmetric 1D hydrodynamic model coupled with a non-local thermodynamic equilibrium model. Comparing synthetic absorption spectra with observations, we constrained the main parameters of the upper atmosphere of these planets and classify them according to their hydrodynamic regime. Our results show that HAT-P-32 b photo-evaporates at (130$\pm$70)$\times$10$^{11}$ gs$^{-1}$ with a hot (12 400$\pm$2900 K) upper atmosphere; WASP-69 b loses its atmosphere at (0.9$\pm$0.5)$\times$10$^{11}$ gs$^{-1}$ and 5250$\pm$750 K; and GJ 1214 b, with a relatively cold outflow of 3750$\pm$750 K, photo-evaporates at (1.3$\pm$1.1)$\times$10$^{11}$ gs$^{-1}$. For WASP-76 b, its weak absorption prevents us from constraining its temperature and mass-loss rate significantly; we obtained ranges of 6000-17 000\,K and 23.5$\pm$21.5$\times$10$^{11}$ gs$^{-1}$. Our reanalysis of GJ 3470 b yields colder temperatures, 3400$\pm$350 K, but practically the same mass-loss rate as in our previous results. Our reanalysis of HD 189733 b yields a slightly higher mass-loss rate, (1.4$\pm$0.5)$\times$10$^{11}$ gs$^{-1}$, and temperature, 12 700$\pm$900 K compared to previous estimates. Our results support that photo-evaporated outflows tend to be very light

Increased Vegetation in Mountainous Headwaters Amplifies Water Stress During Dry Periods

The dynamics of blue and green water partitioning under vegetation and climate change, as well as their different interactions during wet and dry periods, are poorly understood in the literature. We analyzed the impact of vegetation changes on blue water generation in a central Spanish Pyrenees basin undergoing intense afforestation. We found that vegetation change is a key driver of large decreases in blue water availability. The effect of vegetation increase is amplified during dry years, and mainly during the dry season, with streamflow reductions of more than 50%. This pattern can be attributed primarily to increased plant water consumption. Our findings highlight the importance of vegetation changes in reinforcing the decrease in water resource availability. With aridity expected to rise in southern Europe over the next few decades, interactions between climate and land management practices appear to be amplifying future hydrological drought risk in the region.This work was supported by projects CGL2017-82216-R, PCI2019-103631, and PID2019-108589RA-I00 financed by the Spanish Commission of Science and Technology and FEDER; CROSSDRO project financed by AXIS (Assess-ment of Cross(X)-sectoral climate Impacts and pathways for Sustainable transformation), JPI-Climate co-funded call of the European Commission and INDECIS which is part of ERA4CS, an ERA-NET initiated by JPI Climate, and funded by FORMAS (SE), DLR (DE), BMWFW (AT), IFD (DK), MINECO (ES), ANR (FR) with co-funding by the European Union (Grant 690462). Dhais Peña-Angulo received a “Juan de la Cierva” postdoctoral contract (FJCI-2017-33652 Spanish Ministry of Economy and Competitiveness, MEC). Miquel Tomas-Burguera received a “Juan de la Cierva” postdoctoral contract (FJCI-2019-039261-I Spanish Ministry of Science and Innovation). C. Azorin-Molina and S. Grainger. acknowledge funding from the Irish Environmental Protection Agency grant 2019-CCRP-MS.60. C. Juez acknowl-edges funding from the H2020-MSCA-IF-2018 programme (Marie Sklodows-ka-Curie Actions) of the European Union under REA grant agreement, number 834329-SEDILAND

On the study of atmospheric escape of exoplanets using the new window of the He 10830 line

Stars and planetary system

Vaccinate fast but leave no one behind: a call to action for COVID-19 vaccination in Spain

During the first five months of 2021, Spains COVID-19 vaccination campaign progressed slowly and failed to reach marginalised populations. Here, we discuss how, despite recent improvements, it remains important to further engage key stakeholders to ensure nobody is left behind

Meningocele transetmoidal. Diagnóstico en edad adulta: presentación de un caso

La herniación extracraneal de las cubiertas meníngeas, solas o acompañadas de tejido encefálico, a través de un defecto de cierre de los huesos craneales, se define con los términos de meningocele y encefalocele. Estos se pueden clasificar según su contenido o su localización. Los meningoencefaloceles transetmoidales representan el 5% de los meningoencefaloceles, los cuales a su vez constituyen el 8-19% de todos los disrafismos del SNC. Presentamos un caso de una paciente de 54 años de edad con cuadro clínico de rinoliquorrea de 10 años de evolución y meningitis de repetición. Mediante tomografia computadorizada se diagnosticó de un meningocele transetmoidal, que fue tratado satisfactoriamente con cirugía. Ante un paciente con meningitis de repetición, se debe valorar la presencia de rinoliquorrea y, en caso de tenerla, el paciente debe ser sometido a un estudio radiológico exhaustivo, para identificar la solución de continuidad a través de la cual sale el LCR y poder ofrecerle el tratamiento adecuado. Una de las patologías que pueden dar esta manifestación es el meningoencefalocele transetmoidal. El estudio de la fosa anterior con tomografia computadorizada es un buen método para el diagnóstico de esta patología, no obstante, en la actualidad el método de elección es la resonancia magnética

Magnetic Fields in Massive Star-forming Regions (MagMaR). I. Linear Polarized Imaging of the Ultracompact H II Region G5.89-0.39

We report 1.2 mm polarized continuum emission observations carried out with the Atacama Large Millimeter/submillimeter Array toward the high-mass star formation region G5.89-0.39. The observations show a prominent 0.2 pc north-south filamentary structure. The ultracompact H ii region in G5.89-0.39 breaks the filament into two pieces. Its millimeter emission shows a dusty belt with a mass of 55-115 M o˙ and 4500 au in radius, surrounding an inner part comprising mostly ionized gas, with dust emission only accounting for about 30% of the total millimeter emission. We also found a lattice of convex arches that may be produced by dragged dust and gas from the explosive dispersal event involving the O5 Feldt's star. The north-south filament has a mass between 300 and 600 M o˙ and harbors a cluster of about 20 mm envelopes with a median size and mass of 1700 au and 1.5 M o˙, respectively, some of which are already forming protostars. We interpret the polarized emission in the filament as mainly coming from magnetically aligned dust grains. The polarization fraction is ∼4.4% in the filaments and 2.1% at the shell. The magnetic fields are along the North Filament and perpendicular to the South Filament. In the Central Shell, the magnetic fields are roughly radial in a ring surrounding the dusty belt between 4500 and 7500 au, similar to the pattern recently found in the surroundings of Orion BN/KL. This may be an independent observational signpost of explosive dispersal outflows and should be further investigated in other regions.P.S. was partially supported by a Grant-in-Aid for Scientific Research (KAKENHI No. 18H01259) of the Japan Society for the Promotion of Science (JSPS). L.A.Z. acknowledges financial support from CONACyT-280775 and UNAM-PAPIIT IN110618 grants, México. C.L.H.H. acknowledges the support of the NAOJ Fellowship and JSPS KAKENHI grants 18K13586 and 20K14527. J.M.G. is supported by the grant AYA2017-84390-C2-R (AEI/FEDER, EU). K.T. was supported by JSPS KAKENHI grant No. 20H05645. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc